Reducing methane emissions in the United States provides a critical, cost-effective opportunity to address climate change while also yielding immediate benefits, including in human health and agricultural productivity. Moreover, in the United States, significant methane policy opportunities exist not only for the federal government but also for states, cities, businesses, and other non-federal actors. This analysis shows how a comprehensive “All-In” strategy combining actions from different levels of government, and in partnership with businesses and other non-federal actors, can deliver methane emission reductions that exceed 30% by 2030 relative to 2020 levels.